Many studies have shown that the incidence of chromosome abnormalities in early embryos is high (50-70%). Data from oocyte donation shows that women of advanced maternal age (AMA) have decreased delivery rates due to poor oocyte quality. Therefore PGS for infertility has been developed to help women with AMA, recurrent implantation failure (RIF), repeated miscarriage (RM), and other indications. Selecting of chromosomally normal embryos for replacement should increase the implantation rate, reduce spontaneous miscarriage rates and reduce aneuploid conceptions.
Even though the FISH method has been properly standardised, it remains limited to the amount of fluorescent colour dyes available. This limits the number of chromosome DNA probes used simultaneously on one cell; thus requiring one or more extra rounds of hybridisation to analyse more chromosomes.
PGS at Unistel is offered, making use of the FISH procedure, to detect numeric chromosome abnormalities of 6 chromosomes considered to be most involved in aneuploidy and those whose abnormalities may reach term: 13, 15, 16, 18, 21 and 22.
PGS can also be carried out using Array-Comparative Genomic Hybridisation (a-CGH). a-CGH assesses all of the chromosomes. It is a more comprehensive technique that is hypothesize to improve the success rate of IVF.
| Blastomere with normal copy number of chromosomes 13, 18 and 21.
Please do not hesitate to contact the PGD Laboratory with any questions at +27 21 938 9213